A case of rhabdomyolysis with fatal outcome after a
treatment with Levofloxacin. Eur J Clin Pharmacol. 2003
Dec;59(10):779-80. Epub 2003 Oct 24.
Petitjeans F, Nadaud J, Perez JP, Debien B, Olive F, Villevieille
T, Pats B.
Percy Military Hospital, 92140, Clamart, France, cpetitjeans@wanadoo.fr
Fluoroquinolones are known to cause rhabdomyolysis. Levofloxacin
is a recent fluoroquinolone and its muscular toxicity is not well
documented. We describe the case of a 77-year-old female patient,
who presented with an acute rhabdomyolysis after treatment with
Levofloxacin. She had a background of serious cardio-pulmonary
disease. She received an oral ambulatory treatment with Levofloxacin
for pulmonary infection. After 6 days, she presented with severe
rhabdomyolysis, resulting in complete anuria with hyperkalaemia,
complicated with acute liver cytolysis and respiratory failure. The
treatment was a daily repeated haemodialysis. She presented with a
fatal myocardial infarction 13 days after admission. The medical
history inclines us to strongly suspect levofloxacin as the cause of
this severe adverse drug reaction. We also reviewed 27 other suspect
cases reported in the database provided by the World Health
Organization Collaborating Centre for Drug Monitoring (Uppsala,
Sweden). We conclude that rhabdomyolysis can be a rare, severe
adverse effect of levofloxacin, as well as the other
fluoroquinolones. |
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