- [Effects of the combination of new quinolones and a
nonsteroidal anti-inflammatory drug, fenbufen, on the EEG of rabbits]
[Article in Japanese]
Suzuki T, Hara Y, Tamagawa M, Kakizaki K, Murayama S.
Department of Pharmacology, School of Medicine, Chiba University, Japan.
A combination of fenbufen, a non-steroidal anti-inflammatory drug and the
new quinolone produces a central stimulating action. To confirm the
action, we used 6 kinds of new quinolones: enoxacin, norfloxacin,
ofloxacin, ciprofloxacin, lomefloxacin and tosufloxacin in this
experiment. The convulsive effects of these drugs were tested on the EEG
recorded from the neocortex and subcortical regions of the rabbits.
Animals treated with fenbufen (50-200 mg/kg, p.o.) tended to have a high
amplitude slow wave in their EEG. Rabbits treated with the new quinolones
at the dose of 100 mg/kg, p.o., with the exception of tosufloxacin, also
tended to show a high amplitude slow wave in their EEG. Each new quinolone
given 30 min after fenbufen (50 mg/kg, p.o.) elicited characteristic
spikes on the EEG. Then, high-frequency-spikes and epileptiform seizure
waves appeared for a long experimental period with this combination. The
combination of fenbufen and tosufloxacin (100-400 mg/kg, p.o.) caused no
changes in EEG and behavior. The spike and epileptiform wave could be
suppressed only temporarily with diazepam (1-4 mg/kg, i.v.). These results
suggest that combined use of fenbufen and one of the new quinolones,
except for tosufloxacin, produces the seizure. Not only GABA but also
several other mechanisms in the central nervous system may be involved in
the convulsion.
PMID: 1313778 [PubMed - indexed for MEDLINE]
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